Deadpool #45

Final issue! That's right, if you add together all the Deadpool series (creatively) issue 45 is the big 250th issue of Deadpool! What better way to celebrate than to end the series? In our over-sized main story, Ultimatum comes at Deadpool for revenge, so he has no choice but to take them on--all of them. Then, in an Infinity Gauntlet crossover, what would Deadpool do if he got the six gems from Thanos? Plus, a slew of stories showcasing Deadpool's closest friends and allies by special guest writers! Also, a spoiler: Deadpool dies at the end of the issue.

Characters: Apocalypse, Aunt May, Beast, Blind Al, Bob, Agent of HYDRA, Bonebreaker (Marvel), Butler, Cable, Captain America, Carnage, Cyclops, Dazzler, Deadpool, Destiny (Mutant), Doctor Doom, Doctor Octopus, Doctor Strange, Domino, Elektra, Ellie Camacho, Emily Preston, Emma Frost, Flash Thompson, Genesis, George Stacy, Guardian (Marvel), Gwen Stacy, Howard the Duck, Hulk, Impossible Man, Iron Fist, Jeff Preston, John Jameson, Kim, Leather Boy, Lee (Marvel), Lockjaw, Luke Cage, MODOK, Madame Web, Magneto, Man-Thing, Mandrill, Mangog, Mephisto, Michael Hawthorne, Mister Fantastic, Nick Fury, Nick Fury Jr., Nightcrawler, Odin, Pepper Potts, Phil Coulson, Red Skull, Sabretooth, Sasquatch, Scott Adsit, Shane Preston, Shiklah, Shroud, Silver Surfer, Spider-Man, Spider-Woman (Drew), Squirrel Girl, Starfox, Stick, Storm, Thanos, Thing, Thor (Marvel), Venom, X-23